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SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.3
USERS' SCORE
Good
Based on 67 Reviews
8.4
Supplement Facts
Serving Size: Two (2) softgels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Total Carbohydrate
<1 g
<1%**
Vitamin C (as ascorbic acid)
120 mg
133%
Pacran® Whole Fruit Cranberry (Vaccinium macrocarpon)
500 mg
†
Top Medical Research Studies
7
Cranberry products may reduce UTIs
The prevention of urinary tract infections in aged care residents through the use of cranberry products: a critical analysis of the literature.
Directly addresses cranberry's effectiveness
We explored the impact of vaccinium macrocarpon, commonly known as cranberry, on preventing urinary tract infections (UTIs) in aged care residents. The current evidence suggests that cranberry products may help reduce the frequency of UTIs among this demographic, particularly for those who are at heightened risk. However, we noted that the findings are somewhat mixed and incomplete, largely due to insufficient understanding of the active components in cranberries, specifically proanthocyanins.
This analysis highlights the potential benefits of cranberry products for UTI prevention, while also acknowledging the need for further research and education. By better understanding these preventive measures, we could lower antibiotic usage and decrease UTI occurrences in residential aged care settings.
This analysis highlights the potential benefits of cranberry products for UTI prevention, while also acknowledging the need for further research and education. By better understanding these preventive measures, we could lower antibiotic usage and decrease UTI occurrences in residential aged care settings.
Read More
3
Cranberry powder showed no benefit
Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: A 6-month multicenter, randomized, double-blind, placebo-controlled trial.
Direct evaluation of cranberry efficacy
We conducted a 6-month study to understand whether whole cranberry fruit powder could help prevent urinary tract infections (UTIs) in women with a history of recurrent UTIs. Our focus was on 150 healthy females between the ages of 18 and 65 who had experienced either three or more UTIs in the past year or two in the past six months. Participants were randomly assigned to either take 500 mg of cranberry powder daily or a placebo.
Throughout the study, we monitored participants for culture-confirmed UTIs by checking for specific symptoms and conducting tests at various intervals. Unfortunately, our findings showed that the cranberry powder did not significantly impact the incidence of culture-confirmed UTIs, nor did it change safety markers or other related outcomes in the women we studied.
While we hoped to see a positive effect from the cranberry supplement, it's important to report that this study concluded there was no meaningful benefit. Our research provides valuable insights for those considering cranberry as a preventative approach against UTIs, highlighting the need for continued exploration of effective alternatives.
Throughout the study, we monitored participants for culture-confirmed UTIs by checking for specific symptoms and conducting tests at various intervals. Unfortunately, our findings showed that the cranberry powder did not significantly impact the incidence of culture-confirmed UTIs, nor did it change safety markers or other related outcomes in the women we studied.
While we hoped to see a positive effect from the cranberry supplement, it's important to report that this study concluded there was no meaningful benefit. Our research provides valuable insights for those considering cranberry as a preventative approach against UTIs, highlighting the need for continued exploration of effective alternatives.
Read More
9
Vitamin C shows promise for UTIs
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
Strong relevance to UTI treatment
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
Most Useful Reviews
9.5
Effective treatment
Every winter, I suffer from urinary tract infection, often affecting my kidneys. I drink a course of antibiotics monthly. However, taking two cranberry tablets daily from the start of winter resolves this issue, as proven over several years. I opt for different brands based on discounts, and this budget option has worked just as well. As long as the concentration is no less than 500, I'm satisfied.
Read More
9.5
Emotional peace
For two years, I dealt with a urinary tract infection despite consultations with several specialists. After trying many antibiotics with little success, I found this product, which is reputed to combat E-coli. It has significantly eased my distress and gave me a sense of emotional peace. I highly recommend it.
Read More
9.5
Pain relief
After suffering from cystitis for five years, I would wake in pain throughout the night. Taking two pills before bed has really helped; within a week, I felt more relaxed, and the bacteria disappeared. For those with prolonged urinary tract infections, this is highly recommended.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.3
9.5
Vitamin C shows promise for UTIs
Antibacterial effect of vitamin C against uropathogenic E. coli in vitro and in vivo.
Relevant study on vitamin C
We explored the potential of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli (UPEC), which is a major contributor to urinary tract infections (UTIs). This research was motivated by the growing concern over antibiotic resistance, highlighting the need for safer alternatives in UTI treatments.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
Read More
9
Vitamin C shows promise for UTIs
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
Strong relevance to UTI treatment
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
9
Supplement reduces recurrent UTIs
Effects of a supplement associating strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study.
Cranberry effects partially unclear
We investigated the effectiveness of a food supplement containing proanthocyanidin A-rich cranberry extracts (vaccinium macrocarpon) and cinnamon in reducing urinary tract infections (UTIs), particularly recurrent cystitis in women.
In our study, we followed 80 women with a history of cystitis for six months. Half of the participants took the supplement daily while the other half did not. We measured the number of recurrence episodes and assessed symptoms through patient-completed questionnaires.
The results were quite promising. About two-thirds of those using the supplement had no further episodes of cystitis during the six-month period, compared to only one-third of those who didn't take the supplement. Additionally, we noted significant improvements in the frequency and severity of urinary symptoms in those taking the supplement, leading to a better quality of life.
Overall, this study suggests that incorporating vaccinium macrocarpon through supplementation may play a valuable role in managing recurrent urinary infections, providing an alternative for those seeking options beyond antibiotics. The data we've gathered supports the potential benefits of this natural treatment approach.
In our study, we followed 80 women with a history of cystitis for six months. Half of the participants took the supplement daily while the other half did not. We measured the number of recurrence episodes and assessed symptoms through patient-completed questionnaires.
The results were quite promising. About two-thirds of those using the supplement had no further episodes of cystitis during the six-month period, compared to only one-third of those who didn't take the supplement. Additionally, we noted significant improvements in the frequency and severity of urinary symptoms in those taking the supplement, leading to a better quality of life.
Overall, this study suggests that incorporating vaccinium macrocarpon through supplementation may play a valuable role in managing recurrent urinary infections, providing an alternative for those seeking options beyond antibiotics. The data we've gathered supports the potential benefits of this natural treatment approach.
Read More
9
Cranberry juice combats urinary infections
Cranberry Juice, Cranberry Tablets, or Liquid Therapies for Urinary Tract Infection: A Systematic Review and Network Meta-analysis.
Strong relevance to UTI management.
We examined the impacts of vaccinium macrocarpon, commonly known as cranberry, on the management of urinary tract infections (UTIs). Our review focused on several studies that explored how cranberry juice, cranberry tablets, and increased liquid intake affect UTI occurrences.
We found that consuming cranberry juice led to a significantly lower rate of UTIs compared to not receiving any treatment—an impressive 54% reduction. When compared to placebo, the reduction stood at 27%. Additionally, drinking cranberry juice not only helped prevent UTIs but also contributed to a reduction in antibiotic use by 49% compared to placebo and 59% compared to no treatment.
Furthermore, the cranberry compounds also alleviated the symptoms associated with UTIs, making it a beneficial option for managing this common health issue. Overall, the evidence suggests that while increasing fluid intake is helpful in reducing UTIs, cranberry juice provides even better outcomes, offering a promising alternative to traditional antibiotic treatments.
We found that consuming cranberry juice led to a significantly lower rate of UTIs compared to not receiving any treatment—an impressive 54% reduction. When compared to placebo, the reduction stood at 27%. Additionally, drinking cranberry juice not only helped prevent UTIs but also contributed to a reduction in antibiotic use by 49% compared to placebo and 59% compared to no treatment.
Furthermore, the cranberry compounds also alleviated the symptoms associated with UTIs, making it a beneficial option for managing this common health issue. Overall, the evidence suggests that while increasing fluid intake is helpful in reducing UTIs, cranberry juice provides even better outcomes, offering a promising alternative to traditional antibiotic treatments.
Read More
9
Cranberry shows strong UTI prevention
Differences in P-Type and Type 1 Uropathogenic Urinary Anti-Adhesion Activity of Cranberry Fruit Juice Dry Extract Product and D-Mannose Dietary Supplement.
Cranberry's relevance to UTI prevention
We examined the effectiveness of vaccinium macrocarpon, commonly known as cranberry, in combating urinary tract infections (UTIs). Our study focused on the anti-adhesion activity (AAA) of a dry extract from cranberry fruit juice and D-mannose against two types of uropathogenic bacteria most often responsible for UTIs. Using a crossover design, we analyzed the AAA from both supplements through bioassays that measured their effects after consumption.
Results indicated that cranberry juice extract demonstrated a broad-spectrum AAA against the important bacterial types. However, we also uncovered some limitations in the effectiveness of D-mannose when compared to cranberry products. This suggests that while both dietary supplements may offer protection, cranberry extract has specific advantages in preventing UTIs through its unique mechanisms.
This study provides valuable insights for consumers and healthcare professionals, revealing the potential benefits of including cranberry juice extract in dietary routines for UTI prevention. Armed with this knowledge, individuals looking to enhance their urinary health can make informed choices based on the superior anti-adhesion properties of cranberry.
Results indicated that cranberry juice extract demonstrated a broad-spectrum AAA against the important bacterial types. However, we also uncovered some limitations in the effectiveness of D-mannose when compared to cranberry products. This suggests that while both dietary supplements may offer protection, cranberry extract has specific advantages in preventing UTIs through its unique mechanisms.
This study provides valuable insights for consumers and healthcare professionals, revealing the potential benefits of including cranberry juice extract in dietary routines for UTI prevention. Armed with this knowledge, individuals looking to enhance their urinary health can make informed choices based on the superior anti-adhesion properties of cranberry.
Read More
User Reviews
USERS' SCORE
Good
Based on 67 Reviews
8.4
10
Cured chronic cystitis
This supplement is perfect for chronic cystitis! After suffering for a year and several courses of antibiotics, I ordered this supplement and mannose, taking it twice daily. After two months, I feel healthier and require it less frequently. It's safer and more cost-effective than antibiotics, with added benefits for the whole body. My mother also improved significantly after five days. This supplement is now a staple in my medicine cabinet. Many thanks to the manufacturer!
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10
Convenient and effective
This product has greatly assisted me with urinary tract infections. The quality and taste are both excellent, and it's a convenient alternative to antibiotics.
10
Works effectively
These work! They're easy to swallow and effectively ward off urinary tract infections. Take 2 a day, and you're all set!
9.5
Effective treatment
Every winter, I suffer from urinary tract infection, often affecting my kidneys. I drink a course of antibiotics monthly. However, taking two cranberry tablets daily from the start of winter resolves this issue, as proven over several years. I opt for different brands based on discounts, and this budget option has worked just as well. As long as the concentration is no less than 500, I'm satisfied.
Read More
9.5
Emotional peace
For two years, I dealt with a urinary tract infection despite consultations with several specialists. After trying many antibiotics with little success, I found this product, which is reputed to combat E-coli. It has significantly eased my distress and gave me a sense of emotional peace. I highly recommend it.
Read More
